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The films were evaluated for thickness, folding endurance, weight variation, disintegration time, dissolution studies, drug content, and in vitro diffusion test. Compatibility study was carried out using Fourier-transform infrared and differential scanning calorimetry. Formulation was optimized by central composite design. Methods: The MDF was prepared using Kollicoat IR, PEG 400, and spraying technique. Objectives: The aim of the present research is to prepare mouth dissolving film of aprepitant used in the prevention and treatment of post-operative nausea and vomiting. It also provides insight into the latest thin-film products developed by various pharmaceutical companies. At the same time, it provides an overview of the critical parameters associated with formulation design that affect of thin films, including the design of thin films, anatomical and physiological limitations, the selection of appropriate manufacturing processes, characterization techniques, and the physicochemical properties of polymers and drugs. This review examines oral thin films in all aspects from today’s point of view and gives an idea about the growing market share in the world due to the increase in research fields and technological developments. These drug delivery systems can be administered in various ways such as orally, buccally, sublingually, ocularly, and transdermally. Additionally, these systems can be easily applied by themselves, especially for dysphagia patients, geriatric, pediatric, or bedridden patients, as well as patients who cannot easily access water. They are a versatile platform that provides fast, local, or systemic effects. Thin films have been described as an alternative approach to conventional dosage forms. It is mandatory to procure user consent prior to running these cookies on your website.The pharmaceutical industry is attempting to discover thin films as a new drug delivery system. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies will be stored in your browser only with your consent. We also use third-party cookies that help us analyze and understand how you use this website.

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